New sesquiterpene carbonimidic dichlorides and related compounds from the sponge Stylotella aurantium.
作者信息
Musman M, Tanaka J, Higa T
机构信息
Department of Chemistry, Biology, and Marine Science, University of the Ryukyus, Nishihara, Okinawa 903-0213, Japan.
出版信息
J Nat Prod. 2001 Jan;64(1):111-3. doi: 10.1021/np0003342.
PMID:11170682
Abstract
Five new sesquiterpenes (1-5) having a carbonimidic dichloride or an aldehyde function have been isolated, together with seven known related compounds (6-12), from the sponge Stylotella aurantium. The structures of the new compounds were elucidated from spectral data. The absolute stereochemistry of the previously reported reticulidin A (10) was determined. Four of the new compounds showed cytotoxicity with a range of IC(50) values of 0.1-1 microg/mL against several tumor cell lines.
摘要
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