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Inactivation of the plasminogen activator from HeLa cells by peptides of arginine chloromethyl ketone.

作者信息

Coleman P, Kettner C, Shaw E

出版信息

Biochim Biophys Acta. 1979 Jul 11;569(1):41-51. doi: 10.1016/0005-2744(79)90079-2.

DOI:10.1016/0005-2744(79)90079-2
PMID:111716
Abstract

The binding specificities of human urinary urokinase (EC 3.4.99.26) and HeLa cell plasminogen activator were studied using peptidyl chloromethyl ketone inhibitors. A 125I-labeled fibrin assay has been developed to yield kinetic information. Reagents of the sequence X-Gly-ArgCH2Cl were the most effective. The susceptibility of the HeLa cell plasminogen activator differed from that of urokinase in several respects indicating the utility of this type of inhibitor in distinguishing between proteases of this specificity.

摘要

相似文献

1
Inactivation of the plasminogen activator from HeLa cells by peptides of arginine chloromethyl ketone.
Biochim Biophys Acta. 1979 Jul 11;569(1):41-51. doi: 10.1016/0005-2744(79)90079-2.
2
The susceptibility of urokinase to affinity labeling by peptides of arginine chloromethyl ketone.尿激酶对精氨酸氯甲基酮肽亲和标记的敏感性。
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The inactivation of one- and two-chain forms of tissue plasminogen activator by a series of peptidyl chloromethyl ketones.一系列肽基氯甲基酮对组织型纤溶酶原激活物单链和双链形式的失活作用。
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Purification of epidermal plasminogen activator inhibitor.
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Kinetics of the inhibition by plasminogen activator inhibitor 2 of urokinase isolated from human urine and recombinant microorganisms. Further evidence for correct tertiary structure of recombinant urokinase.纤溶酶原激活物抑制剂2对从人尿及重组微生物中分离的尿激酶的抑制动力学。重组尿激酶正确三级结构的进一步证据。
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[Identity of kininogenase and plasminogen activators in human granulocytes].
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8
A cyclopeptidic suicide substrate preferentially inactivates urokinase-type plasminogen activator.一种环肽类自杀底物优先使尿激酶型纤溶酶原激活剂失活。
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The irreversible inhibition of urokinase, kidney-cell plasminogen activator, plasmin and beta-trypsin by 1-(N-6-amino-n-hexyl)carbamoylimidazole.1-(N-6-氨基正己基)氨基甲酰咪唑对尿激酶、肾细胞纤溶酶原激活物、纤溶酶和β-胰蛋白酶的不可逆抑制作用
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Interfering factors in the assay of plasminogen activators by the fibrin plate method. Occurrence of different inhibitors against tissue plasminogen activator and urokinase.用纤维蛋白平板法测定纤溶酶原激活剂时的干扰因素。针对组织纤溶酶原激活剂和尿激酶的不同抑制剂的出现情况。
Thromb Haemost. 1979 May 25;41(3):590-600.

引用本文的文献

1
Active site directed inhibitor used in the production of antibodies against urokinase.用于生产抗尿激酶抗体的活性位点定向抑制剂。
J Clin Pathol. 1984 Oct;37(10):1193-4. doi: 10.1136/jcp.37.10.1193.
2
In vivo distribution of Tc-99m labeled recombinant tissue-type plasminogen activator in control and thrombus-bearing rats.锝-99m标记的重组组织型纤溶酶原激活剂在对照大鼠和有血栓大鼠体内的分布
Ann Nucl Med. 1992 Aug;6(3):177-84. doi: 10.1007/BF03178310.