纤溶酶原激活物抑制剂2对从人尿及重组微生物中分离的尿激酶的抑制动力学。重组尿激酶正确三级结构的进一步证据。
Kinetics of the inhibition by plasminogen activator inhibitor 2 of urokinase isolated from human urine and recombinant microorganisms. Further evidence for correct tertiary structure of recombinant urokinase.
作者信息
Cramer J, Steffens G, Günzler W A, Hess V, Flohé L
机构信息
Center of Research, Grünenthal GmbH, Aachen Fed. Rep. of Germany.
出版信息
Arzneimittelforschung. 1988 Aug;38(8):1196-8.
PMID:3143371
Abstract
The specific plasminogen activator inhibitor 2 (PAI-2) from human placenta was used to compare the kinetics of inactivation of recombinant urokinase and urokinase from human urine. The inactivation of the enzymes proceeded with identical second order rate constants. The result is considered a further indication of corresponding 3-dimensional structures of urokinases from human urine and of recombinant origin.
摘要
用人胎盘来源的特异性纤溶酶原激活物抑制剂2（PAI-2）比较重组尿激酶和人尿源性尿激酶的失活动力学。两种酶的失活过程具有相同的二级速率常数。该结果被认为进一步表明人尿源性尿激酶和重组尿激酶具有相应的三维结构。
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