卡波西肉瘤病因学与消退中的矛盾概念。费伦茨·乔尔凯纪念讲座。
Contradictory Concepts in the Etiology and Regression of Kaposi's Sarcoma. The Ferenc Györkey Memorial Lecture.
作者信息
Sinkovics Joseph G
机构信息
University of South Florida College of Medicine, Cancer Institute St. Joseph's Hospital & Departments of Medicine & Medical Microbiology, Tampa, USA.
出版信息
Pathol Oncol Res. 1996;2(4):249-267. doi: 10.1007/BF02904821.
The Introduction is an overview of 3 decades of works performed by Professor Ferenc Györkey (in many cases in collaboration with the author) and aimed at the elucidation of viral participation in the etiology of arteriosclerosis, SLE, hairy cell leukemia, HD, AIDS and KS. Controversial issues surrounding the etiology, treatment and regression of KS are discussed in terms of paracrine and autocrine loops of growth factors; protooncogene-oncogene activations, immunosuppression and retro- and/or herpesviral etiology. In regressing KS lesions the roles played by Fas, Bcl-2, Bax, TNFß; apoptotic-antiapoptotic events; and antiangiogenesis agents especially that of Hu-r-IFNa are elaborated on.
引言部分概述了费伦茨·杰尔凯伊教授（在许多情况下是与作者合作）三十年来的研究工作，旨在阐明病毒在动脉硬化、系统性红斑狼疮、毛细胞白血病、霍奇金病、艾滋病和卡波西肉瘤病因中的作用。围绕卡波西肉瘤的病因、治疗和消退的争议性问题，从生长因子的旁分泌和自分泌环、原癌基因 - 癌基因激活、免疫抑制以及逆转录和/或疱疹病毒病因等方面进行了讨论。在卡波西肉瘤病变消退过程中，阐述了Fas、Bcl - 2、Bax、TNFβ所起的作用；凋亡 - 抗凋亡事件；以及抗血管生成剂，尤其是Hu - r - IFNa的作用。
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