Li R, Pei H, Watson D K
Center for Molecular and Structural Biology, Medical University of South Carolina, Charleston, South Carolina, SC 29425, USA.
Oncogene. 2000 Dec 18;19(55):6514-23. doi: 10.1038/sj.onc.1204035.
Ets proteins are a family of transcription factors that share an 85 amino acid conserved DNA binding domain, the ETS domain. Over 25 mammalian Ets family members control important biological processes, including cellular proliferation, differentiation, lymphocyte development and activation, transformation and apoptosis by recognizing the GGA core motif in the promoter or enhancer of their target genes. Protein - protein interactions regulates DNA binding, subcellular localization, target gene selection and transcriptional activity of Ets proteins. Combinatorial control is a characteristic property of Ets family members, involving interaction between Ets and other key transcriptional factors such as AP-1, NFkappaB and Pax family members. Specific domains of Ets proteins interact with many protein motifs such as bHLH, bZipper and Paired domain. Such interactions coordinate cellular processes in response to diverse signals including cytokines, growth factors, antigen and cellular stresses.
Ets蛋白是一类转录因子家族，它们共享一个由85个氨基酸组成的保守DNA结合结构域，即ETS结构域。超过25个哺乳动物Ets家族成员通过识别其靶基因启动子或增强子中的GGA核心基序，控制重要的生物学过程，包括细胞增殖、分化、淋巴细胞发育和激活、转化及凋亡。蛋白质-蛋白质相互作用调节Ets蛋白的DNA结合、亚细胞定位、靶基因选择和转录活性。组合控制是Ets家族成员的一个特征属性，涉及Ets与其他关键转录因子如AP-1、NFκB和Pax家族成员之间的相互作用。Ets蛋白的特定结构域与许多蛋白质基序相互作用，如bHLH、bZipper和配对结构域。这种相互作用响应包括细胞因子、生长因子、抗原和细胞应激在内的多种信号来协调细胞过程。
