Verger Alexis, Duterque-Coquillaud Martine
CNRS UMR 8526, Institut de Biologie de Lille, B.P. 447, 1 rue Calmette, 59021 Lille Cedex, France.
Bioessays. 2002 Apr;24(4):362-70. doi: 10.1002/bies.10068.
Ets proteins are a family of transcription factors that regulate the expression of a myriad of genes in a variety of tissues and cell types. This functional versatility emerges from their interactions with other structurally unrelated transcription factors. Indeed, combinatorial control is a characteristic property of Ets family members, involving interactions between Ets and other key transcriptional factors such as AP1, SRF, and Pax family members. Intriguingly, recent molecular modeling and crystallographic data suggest that not only the ETS DNA-binding domain, but also the DNA recognition helix alpha3, are often directly required for Ets partner's selection. Indeed, while most DNA-binding proteins appear to exploit differences within their DNA recognition helices for sites selection, the Ets proteins exploit differences in their surfaces that interact with other transcription factors, which in turn may modify their DNA-binding properties in a promoter-specific fashion. Taken together, the gene-specific architecture of these unique complexes can mediate the selective control of transcriptional activity.
Ets蛋白是一类转录因子家族，可调节多种组织和细胞类型中无数基因的表达。这种功能的多样性源于它们与其他结构不相关的转录因子的相互作用。实际上，组合控制是Ets家族成员的一个特征属性，涉及Ets与其他关键转录因子（如AP1、SRF和Pax家族成员）之间的相互作用。有趣的是，最近的分子建模和晶体学数据表明，不仅ETS DNA结合结构域，而且DNA识别螺旋α3，通常也是Ets伙伴选择直接需要的。事实上，虽然大多数DNA结合蛋白似乎利用其DNA识别螺旋内的差异进行位点选择，但Ets蛋白利用其与其他转录因子相互作用的表面差异，这反过来可能以启动子特异性方式改变其DNA结合特性。总之，这些独特复合物的基因特异性结构可以介导转录活性的选择性控制。
