John S, Krishnaswami S, Jairaj P S, Cherian G, Muralidharan S, Sukumar I P
J Thorac Cardiovasc Surg. 1975 Apr;69(4):631-8.
Mitral stenosis in the younger age groups in India is a unique condition characterized by a short duration and a rapid progression of symptoms. The majority of patients with this lesion develop pulmonary hypertension at an accelerated pace, and about one third have associated congestive failure and functional tricuspid regurgitation. Five hundred consecutive patients with this condition were treated surgically, 493 with a closed valvotomy. The over-all hospital mortality rate of 5.8 per cent was related to the severity of the preoperative functional status. In the last 150 cases, the figure dropped to 2 per cent. Assessment during the first 5 years after surgery revealed an excellent functional status in 85 per cent. The incidence of restenosis was only 3.4 per cent in the first 5 year period and 11 per cent in a subsequent 6 to 10 year follow-up period. Twenty of the 21 subjects with restenosis had an excellent functional result following closed transventricular valvotomy, and this status has been maintained during the follow-up period. To our knowledge, there are no other reports of long-term follow-up data in young patients undergoing surgical treatment for mitral stenosis.
在印度，年轻人群中的二尖瓣狭窄是一种独特的病症，其特点是病程短且症状进展迅速。大多数患有这种病变的患者会加速发展为肺动脉高压，约三分之一的患者伴有充血性心力衰竭和功能性三尖瓣反流。连续500例患有这种病症的患者接受了手术治疗，其中493例接受了闭式瓣膜切开术。总体医院死亡率为5.8%，这与术前功能状态的严重程度有关。在最后150例病例中，该数字降至2%。术后前5年的评估显示，85%的患者功能状态良好。再狭窄发生率在最初5年期间仅为3.4%，在随后6至10年的随访期为11%。21例再狭窄患者中有20例在接受经心室闭式瓣膜切开术后功能恢复良好，并且在随访期间一直保持这种状态。据我们所知，尚无其他关于接受二尖瓣狭窄手术治疗的年轻患者长期随访数据的报道。
