Murphy J T, Kwan H C, Wong Y C
Brain Res. 1979 Aug 24;172(2):329-37. doi: 10.1016/0006-8993(79)90542-0.
The present study was undertaken to investigate the functional significance of previous observations that both reciprocal and bidirectional responses are found in the forelimb area of precentral cortex following oppositely directed torques delivered about a single forelimb joint. Extracellular unit recordings were made in the contralateral precentral cortex of awake monkeys. These units were classified, according to their responses to passive somatosensory stimulation and to the effects of local intracortical microstimulation (ICMS), as being functionally coupled to single joints. Both joint- and cutaneous-sensitive neurons were included. The responses of such classified neurons to oppositely directed torques were then studied. All of the joint-sensitive wrist (flexion-extension) units responded reciprocally to the oppositely directed torques. In contrast reciprocally and bidirectionally responsive neurons were found in the cutaneous-sensitive wrist population and in both the joint- and cutaneous-sensitive non-wrist (F-E) populations. These results are discussed in terms of the expected receptor actions of the applied torques, and are consistent with other evidence that a correlation exists between activities of precentral neurons which respond to sensory events at or about a single forelimb joint, and voluntary movement about the same joint.
本研究旨在探讨先前观察结果的功能意义，即在围绕单个前肢关节施加相反方向的扭矩后，在中央前回前肢区域发现了相互和双向反应。在清醒猴子的对侧中央前回进行细胞外单位记录。根据这些单位对被动体感刺激和局部皮质内微刺激（ICMS）的反应，将它们分类为在功能上与单个关节耦合。包括关节敏感神经元和皮肤敏感神经元。然后研究了此类分类神经元对相反方向扭矩的反应。所有关节敏感的腕关节（屈伸）单位对相反方向的扭矩都有相互反应。相比之下，在皮肤敏感的腕关节群体以及关节和皮肤敏感的非腕关节（屈伸）群体中都发现了相互和双向反应的神经元。根据所施加扭矩的预期感受器作用对这些结果进行了讨论，并且与其他证据一致，即对单个前肢关节处或附近的感觉事件作出反应的中央前神经元的活动与围绕同一关节的自主运动之间存在相关性。
