Maine E M
Department of Biology, Syracuse University, Syracuse, NY 13244, USA.
Genome Biol. 2000;1(3):REVIEWS1018. doi: 10.1186/gb-2000-1-3-reviews1018. Epub 2000 Sep 13.
Proteins with homology to RNA-directed RNA polymerases function in post-transcriptional gene silencing: in quelling in the fungus Neurospora crassa, RNAi in the nematode Caenorhabditis elegans, and co-suppression in the mustard plant Arabidopsis thaliana. These findings are consistent with a conserved mechanism operating in these diverse species.
与RNA指导的RNA聚合酶具有同源性的蛋白质在转录后基因沉默中发挥作用:在真菌粗糙脉孢菌中的基因压制、线虫秀丽隐杆线虫中的RNA干扰以及芥菜植物拟南芥中的共抑制。这些发现与在这些不同物种中起作用的保守机制一致。