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转录后基因沉默的保守机制？

A conserved mechanism for post-transcriptional gene silencing?

作者信息

Maine E M

机构信息

Department of Biology, Syracuse University, Syracuse, NY 13244, USA.

出版信息

Genome Biol. 2000;1(3):REVIEWS1018. doi: 10.1186/gb-2000-1-3-reviews1018. Epub 2000 Sep 13.

DOI:10.1186/gb-2000-1-3-reviews1018
PMID:11178243
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC138860/
Abstract

Proteins with homology to RNA-directed RNA polymerases function in post-transcriptional gene silencing: in quelling in the fungus Neurospora crassa, RNAi in the nematode Caenorhabditis elegans, and co-suppression in the mustard plant Arabidopsis thaliana. These findings are consistent with a conserved mechanism operating in these diverse species.

摘要

与RNA指导的RNA聚合酶具有同源性的蛋白质在转录后基因沉默中发挥作用：在真菌粗糙脉孢菌中的基因压制、线虫秀丽隐杆线虫中的RNA干扰以及芥菜植物拟南芥中的共抑制。这些发现与在这些不同物种中起作用的保守机制一致。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b157/138860/938d681d7f97/gb-2000-1-3-reviews1018-1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b157/138860/938d681d7f97/gb-2000-1-3-reviews1018-1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b157/138860/938d681d7f97/gb-2000-1-3-reviews1018-1.jpg

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1
A conserved mechanism for post-transcriptional gene silencing?转录后基因沉默的保守机制？
Genome Biol. 2000;1(3):REVIEWS1018. doi: 10.1186/gb-2000-1-3-reviews1018. Epub 2000 Sep 13.
2
An RNA-dependent RNA polymerase gene in Arabidopsis is required for posttranscriptional gene silencing mediated by a transgene but not by a virus.拟南芥中的一个依赖RNA的RNA聚合酶基因对于由转基因介导而非病毒介导的转录后基因沉默是必需的。
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Gene silencing in Neurospora crassa requires a protein homologous to RNA-dependent RNA polymerase.粗糙脉孢菌中的基因沉默需要一种与RNA依赖性RNA聚合酶同源的蛋白质。
Nature. 1999 May 13;399(6732):166-9. doi: 10.1038/20215.
4
The RNA-dependent RNA polymerase, QDE-1, is a rate-limiting factor in post-transcriptional gene silencing in Neurospora crassa.RNA依赖的RNA聚合酶QDE-1是粗糙脉孢菌转录后基因沉默中的一个限速因子。
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本文引用的文献

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Introduction of a Chimeric Chalcone Synthase Gene into Petunia Results in Reversible Co-Suppression of Homologous Genes in trans.将嵌合查尔酮合酶基因导入矮牵牛导致同源基因的反式可逆共抑制。
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Cell. 2000 May 26;101(5):543-53. doi: 10.1016/s0092-8674(00)80864-8.
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Arabidopsis SGS2 and SGS3 genes are required for posttranscriptional gene silencing and natural virus resistance.
解析单倍型的抗和感双生病毒的非洲木薯品种基因组。
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Nucleic Acids Res. 2002 Nov 1;30(21):4709-19. doi: 10.1093/nar/gkf591.
拟南芥SGS2和SGS3基因是转录后基因沉默和天然病毒抗性所必需的。
Cell. 2000 May 26;101(5):533-42. doi: 10.1016/s0092-8674(00)80863-6.
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Gene silencing in worms and fungi.蠕虫和真菌中的基因沉默
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