Gladtke E
Monatsschr Kinderheilkd (1902). 1975 Jan;123(1):15-6.
Over the last twenty years drug therapy for the newborn and young infant has developed from its empirical origins to a state where the results of intensive research can be applied. As biochemical studies have shown, enzyme activities and the mechanisms of detoxification are dependent on age. These findings have prompted pharmacokinetic considerations with regard to dosage, especially in repetitive dosage regimens. Further aspects include interference and in particular the protein-binding of drugs in the newborn, side effects of drugs administered to the expectant mother, only seen later in their infants, and side effects characteristic for the newborn. Finally mention is made of some recent advances in pediatric antimicrobial therapy. The most frequent side effect is the inefficiency of drugs because of underdosage.
在过去的二十年里，新生儿和婴幼儿的药物治疗已从经验性起源发展到能够应用深入研究成果的阶段。正如生化研究所示，酶活性和解毒机制取决于年龄。这些发现促使人们在剂量方面进行药代动力学考量，尤其是在重复给药方案中。其他方面还包括干扰因素，特别是新生儿体内药物与蛋白质的结合、给准妈妈用药后在其婴儿身上才显现的副作用，以及新生儿特有的副作用。最后提及了儿科抗菌治疗方面的一些最新进展。最常见的副作用是由于剂量不足导致药物疗效不佳。
