人类细胞会修复被亚硝酸损伤的DNA。
Human cells repair DNA damaged by nitrous acid.
作者信息
Day R S
出版信息
Mutat Res. 1975 Mar;27(3):407-9. doi: 10.1016/0027-5107(75)90298-5.
PMID:1117879
Abstract
Cultured fibroblasts from normal persons or persons afflicted by xeroderma pigmentosum were used as hosts for adenovirus 2 infection. With xeroderma cells as hosts, nitrous acid-treated virus showed less plaque-forming ability than when normal cells were used, indicating that DNA damaged by nitrous acid is at least partly repaired by normal human cells.
摘要
来自正常人或患着色性干皮病的人的培养成纤维细胞被用作腺病毒2感染的宿主。以着色性干皮病细胞作为宿主时，经亚硝酸处理的病毒形成蚀斑的能力比以正常细胞作为宿主时要弱，这表明被亚硝酸损伤的DNA至少部分会被正常人体细胞修复。
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