Belda Sanchís J I, Quijada González A, Muñoz Ruiz G, Rodríguez-Galietero A, Romero Gómez F J, Díaz-Llopis M
Unidad de Toxicología Experimental y Neurotoxicología, Departamento de Fisiología, Universidad de Valencia, Valencia, España.
Arch Soc Esp Oftalmol. 2001 Jan;76(1):13-7.
To study the levels of lipids in serum, in patients with age-related macular degeneration (AMD), and to establish its pathogenic relevance in the disease.
The serums of a total of 40 patients, distributed in a AMD group (25 patients) and a control group (15 patients, with similar ages and without ocular affectation) were studied, correlating the biochemical findings with the clinical examination of these patients.
We have observed a mean level of serum total cholesterol statistically superior in AMD patients (control= 200.18+/-18.89 mg/dL; AMD= 227.28+/-5.46 mg/dL; p<0.01). These significant differences are repeated for different lipoproteins (triglycerides, LDL, VLDL and apolipoprotein B), not appearing for the HDL and apolipoprotein A-1. We have not found correlations of these concentrations with the clinical or functional stage of the AMD.
Serum lipids could take part in the pathogenic mechanism of AMD, either by their relation with arteriosclerosis, which would diminish the choroidal flow, or by direct deposit in the Bruch's membrane. However, more longitudinal studies are needed to understand the relation of serum lipids and AMD, and to establish therapeutic approaches on the matter.
研究年龄相关性黄斑变性（AMD）患者血清中的脂质水平，并确定其在该疾病中的致病相关性。
共研究了40例患者的血清，分为AMD组（25例患者）和对照组（15例年龄相仿且无眼部病变的患者），将生化检查结果与这些患者的临床检查结果进行关联分析。
我们观察到AMD患者血清总胆固醇的平均水平在统计学上高于对照组（对照组 = 200.18±18.89 mg/dL；AMD组 = 227.28±5.46 mg/dL；p<0.01）。不同脂蛋白（甘油三酯、低密度脂蛋白、极低密度脂蛋白和载脂蛋白B）也存在类似的显著差异，而高密度脂蛋白和载脂蛋白A-1则无此差异。我们未发现这些浓度与AMD的临床或功能分期存在相关性。
血清脂质可能通过与动脉硬化的关系（这会减少脉络膜血流）或直接沉积在 Bruch 膜中参与AMD的致病机制。然而，需要更多的纵向研究来了解血清脂质与AMD的关系，并在此基础上建立治疗方法。
