豆科、木犀科、山梅花科、蔷薇科和省沽油科植物提取物的细胞毒性作用。
Cytotoxic effects of plant extracts from the families Fabaceae, Oleaceae, Philadelphaceae, Rosaceae and Staphyleaceae.
作者信息
Jantova S, Nagy M, Ruzeková L, Grancai D
机构信息
Department of Biochemistry and Microbiology, Faculty of Chemical Technology, Slovak University of Technology, Radlinského 9, 812 37 Bratislava, Slovakia.
出版信息
Phytother Res. 2001 Feb;15(1):22-5. doi: 10.1002/1099-1573(200102)15:1<22::aid-ptr774>3.0.co;2-a.
A human transformed line of HeLa cells was treated with extracts prepared from Gymnocladus dioicus, Holodiscus discolor, Stephanandra tanakae, Ligustrum delavayanum, Ligustrum vulgare and Staphylea pinnata. The study evaluating the influence of the active extracts on HeLa cell division also reveals their acute, delayed and combined effect. A 35% degradation of HeLa cells was found after 72 h treatment with 62.5 microg/mL of the extract isolated from Stephanandra tanakae. A 100% lysis of HeLa cells was observed after 72 h treatment with a 125 microg/mL concentration of the extract prepared from Gymnocladus dioicus. The extracts from Ligustrum devayanum and Ligustrum vulgare were specifically effective only with HeLa cells. On the other hand, the extract prepared from Gymnocladus dioicus was effective on the bacteria and on the HeLa cells.
用人参提取物处理人源HeLa细胞系。该研究评估了活性提取物对HeLa细胞分裂的影响，同时揭示了它们的急性、延迟和联合效应。用从野鸦椿中分离出的提取物以62.5微克/毫升处理72小时后，发现HeLa细胞降解了35%。用125微克/毫升浓度的从皂荚中制备的提取物处理72小时后，观察到HeLa细胞100%裂解。从长叶女贞和欧洲女贞中提取的提取物仅对HeLa细胞有特效。另一方面，从皂荚中制备的提取物对细菌和HeLa细胞均有效。
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