Saad Fred, Gu Kefeng, Jean-Baptiste Johanne, Gauthier Jean, MesMasson Anne-Marie
CHUM-Pavillon Notre-Dame and Institut du cancer de Montréal.
Can J Urol. 1999 Aug;6(4):834-838.
An etiological role for human papilloma viruses (HPVs) has been proposed for a variety of malignancies, and especially in cervical carcinomas. The role of HPVs in prostate cancer remains controversial. In particular, using primers derived from the L1 gene of HPV, it has been suggested that HPV sequences are associated with prostate malignancies. PCR and Southern blot hybridization was used to detect the presence of HPV DNA in fresh tissue from patients undergoing radical prostatectomy for prostate cancer. In total, 40 individual patients were analyzed and none of the samples contained detectable HPV DNA sequences.
人类乳头瘤病毒（HPV）被认为在多种恶性肿瘤，尤其是宫颈癌的发病机制中发挥作用。HPV在前列腺癌中的作用仍存在争议。特别是，有人使用源自HPV L1基因的引物，认为HPV序列与前列腺恶性肿瘤有关。采用聚合酶链反应（PCR）和Southern印迹杂交技术检测接受前列腺癌根治性切除术患者新鲜组织中HPV DNA的存在情况。总共分析了40例患者，所有样本均未检测到可检测到的HPV DNA序列。
