肿瘤抑制的单倍剂量不足：单身且长寿的风险。 - Suppr

Suppr

超能文献

Haploinsufficiency for tumor suppression: the hazards of being single and living a long time.

作者信息

Largaespada D A

机构信息

Department of Genetics, Cell Biology, and Development, University of Minnesota, Minneapolis, Minnesota 55455, USA.

出版信息

J Exp Med. 2001 Feb 19;193(4):F15-8. doi: 10.1084/jem.193.4.f15.

DOI:10.1084/jem.193.4.f15

PMID:11181707

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2195912/

Abstract

摘要

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5854/2195912/66ee918ff351/JEM010122.f1.jpg

相似文献

Haploinsufficiency for tumor suppression: the hazards of being single and living a long time.肿瘤抑制的单倍剂量不足：单身且长寿的风险。

J Exp Med. 2001 Feb 19;193(4):F15-8. doi: 10.1084/jem.193.4.f15.

BCL-2 cooperates with promyelocytic leukemia retinoic acid receptor alpha chimeric protein (PMLRARalpha) to block neutrophil differentiation and initiate acute leukemia.BCL-2与早幼粒细胞白血病视黄酸受体α嵌合蛋白（PMLRARα）协同作用，以阻断中性粒细胞分化并引发急性白血病。

J Exp Med. 2001 Feb 19;193(4):531-43. doi: 10.1084/jem.193.4.531.

Cancer research. Leukemia protein spurs gene silencing.癌症研究。白血病蛋白促进基因沉默。

Science. 2002 Feb 8;295(5557):943-5. doi: 10.1126/science.295.5557.943b.

[Advances in the study of etiology and differentiation induction mechanism of acute promyelocytic leukemia].[急性早幼粒细胞白血病的病因及分化诱导机制研究进展]

Zhonghua Xue Ye Xue Za Zhi. 1999 Dec;20(12):666-8.

Dysregulation of BCL-2 family proteins by leukemia fusion genes.白血病融合基因导致BCL-2家族蛋白失调。

J Biol Chem. 2017 Sep 1;292(35):14325-14333. doi: 10.1074/jbc.R117.799056. Epub 2017 Jul 17.

[The relationship between clinical prognosis and classification of the isoforms of fuse gene in acute promyelocytic leukemia].

Hunan Yi Ke Da Xue Xue Bao. 2000 Dec 28;25(6):564-6.

A RA-dependent, tumour-growth suppressive transcription complex is the target of the PML-RARalpha and T18 oncoproteins.一种依赖于视黄酸的肿瘤生长抑制转录复合体是早幼粒细胞白血病-维甲酸受体α（PML-RARα）和T18癌蛋白的作用靶点。

Nat Genet. 1999 Nov;23(3):287-95. doi: 10.1038/15463.

A new PML-RARs fusion transcript hints at the important role of PML dysregulation in the pathogenesis of APL.一种新的PML-RARs融合转录本提示PML失调在急性早幼粒细胞白血病发病机制中起重要作用。

Leuk Lymphoma. 2007 Mar;48(3):443-4. doi: 10.1080/10428190601186184.

The puzzling multiple lives of PML and its role in the genesis of cancer.进行性多灶性白质脑病的复杂多面性及其在癌症发生中的作用。

Bioessays. 2000 Sep;22(9):827-35. doi: 10.1002/1521-1878(200009)22:9<827::AID-BIES8>3.0.CO;2-1.

[Acute promyelocytic leukemia, histone deacetylase, and response to retinoids].[急性早幼粒细胞白血病、组蛋白去乙酰化酶与维甲酸反应]

Bull Cancer. 1998 Apr;85(4):301-3.

引用本文的文献

Of numbers and movement - understanding transcription factor pathogenesis by advanced microscopy.从数字和运动角度理解先进显微镜下转录因子发病机制

Dis Model Mech. 2020 Dec 29;13(12):dmm046516. doi: 10.1242/dmm.046516.

Driver gene alterations and activated signaling pathways toward malignant progression of gastrointestinal stromal tumors.胃肠道间质瘤恶性进展的驱动基因改变和激活的信号通路。

Cancer Sci. 2019 Dec;110(12):3821-3833. doi: 10.1111/cas.14202. Epub 2019 Oct 14.

Recent Advances in the 5q- Syndrome.5q-综合征的最新进展

Mediterr J Hematol Infect Dis. 2015 May 20;7(1):e2015037. doi: 10.4084/MJHID.2015.037. eCollection 2015.

The utility of Apc-mutant rats in modeling human colon cancer.Apc 突变大鼠在人类结肠癌建模中的应用。

Dis Model Mech. 2014 Nov;7(11):1215-25. doi: 10.1242/dmm.016980. Epub 2014 Oct 2.

-7/7q- syndrome in myeloid-lineage hematopoietic malignancies: attempts to understand this complex disease entity.7/7q- 综合征在髓系造血恶性肿瘤中的研究进展：尝试理解这种复杂的疾病实体。

Oncogene. 2015 May 7;34(19):2413-25. doi: 10.1038/onc.2014.196. Epub 2014 Jul 7.

A strategy to identify dominant point mutant modifiers of a quantitative trait.一种识别数量性状显性点突变修饰因子的策略。

G3 (Bethesda). 2014 Apr 17;4(6):1113-21. doi: 10.1534/g3.114.010595.

RADIOSENSITIVITY TO HIGH ENERGY IRON IONS IS INFLUENCED BY HETEROZYGOSITY for and .对高能铁离子的辐射敏感性受和的杂合性影响。

Adv Space Res. 2010 Sep 1;46(6):681-686. doi: 10.1016/j.asr.2010.02.026.

The role of haploinsufficiency of RPS14 and p53 activation in the molecular pathogenesis of the 5q- syndrome.RPS14单倍剂量不足和p53激活在5q-综合征分子发病机制中的作用。

Pediatr Rep. 2011 Jun 22;3 Suppl 2(Suppl 2):e10. doi: 10.4081/pr.2011.s2.e10.

Rara haploinsufficiency modestly influences the phenotype of acute promyelocytic leukemia in mice.罕见的单倍体不足对小鼠急性早幼粒细胞白血病的表型有一定影响。

Blood. 2011 Feb 24;117(8):2460-8. doi: 10.1182/blood-2010-08-300087. Epub 2010 Dec 29.

Haploinsufficiency of Apc leads to ineffective hematopoiesis.Apc 杂合性缺失导致无效造血。

Blood. 2010 Apr 29;115(17):3481-8. doi: 10.1182/blood-2009-11-251835. Epub 2010 Jan 11.

本文引用的文献

J Exp Med. 2001 Feb 19;193(4):531-43. doi: 10.1084/jem.193.4.531.

Role of promyelocytic leukemia (PML) protein in tumor suppression.早幼粒细胞白血病（PML）蛋白在肿瘤抑制中的作用。

J Exp Med. 2001 Feb 19;193(4):521-29. doi: 10.1084/jem.193.4.521.

Acute promyelocytic leukemia (AML-M3)--Part 2: Molecular defect, DNA diagnosis, and proposed models of leukemogenesis and differentiation therapy.急性早幼粒细胞白血病（AML-M3）——第二部分：分子缺陷、DNA诊断以及白血病发生和分化治疗的提出模型

Clin Lab Sci. 2000 Spring;13(2):106-16.

Characterization of acute promyelocytic leukemia cases lacking the classic t(15;17): results of the European Working Party. Groupe Français de Cytogénétique Hématologique, Groupe de Français d'Hematologie Cellulaire, UK Cancer Cytogenetics Group and BIOMED 1 European Community-Concerted Action "Molecular Cytogenetic Diagnosis in Haematological Malignancies".缺乏经典t(15;17)的急性早幼粒细胞白血病病例的特征：欧洲工作组的结果。法国血液细胞遗传学小组、法国血液细胞学小组、英国癌症细胞遗传学小组以及生物医药1欧洲共同体协调行动“血液系统恶性肿瘤的分子细胞遗传学诊断”

Blood. 2000 Aug 15;96(4):1297-308.

p27KIP1 deletions in childhood acute lymphoblastic leukemia.儿童急性淋巴细胞白血病中的p27KIP1缺失

Neoplasia. 1999 Aug;1(3):253-61. doi: 10.1038/sj.neo.7900033.

Role of the transcription factor AML-1 in acute leukemia and hematopoietic differentiation.转录因子AML-1在急性白血病和造血分化中的作用。

Gene. 2000 Mar 21;245(2):223-35. doi: 10.1016/s0378-1119(00)00014-7.

A bcr-3 isoform of RARalpha-PML potentiates the development of PML-RARalpha-driven acute promyelocytic leukemia.维甲酸受体α-早幼粒细胞白血病蛋白（RARα-PML）的bcr-3亚型增强了PML-RARα驱动的急性早幼粒细胞白血病的发展。

Proc Natl Acad Sci U S A. 1999 Dec 21;96(26):15103-8. doi: 10.1073/pnas.96.26.15103.

Haploinsufficiency of CBFA2 causes familial thrombocytopenia with propensity to develop acute myelogenous leukaemia.CBFA2单倍剂量不足会导致家族性血小板减少症，并易发展为急性髓性白血病。

Nat Genet. 1999 Oct;23(2):166-75. doi: 10.1038/13793.

The murine gene p27Kip1 is haplo-insufficient for tumour suppression.小鼠基因p27Kip1在肿瘤抑制方面存在单倍体不足。

Nature. 1998 Nov 12;396(6707):177-80. doi: 10.1038/24179.

PML is essential for multiple apoptotic pathways.早幼粒细胞白血病蛋白（PML）对多种凋亡途径至关重要。

Nat Genet. 1998 Nov;20(3):266-72. doi: 10.1038/3073.

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验