在GABA能突触处产生多样性。

Generating diversity at GABAergic synapses.

作者信息

Cherubini E, Conti F

机构信息

Biophysics Sector, International School of Advanced Studies, I-34014 Trieste, Italy.

出版信息

Trends Neurosci. 2001 Mar;24(3):155-62. doi: 10.1016/s0166-2236(00)01724-0.

DOI:10.1016/s0166-2236(00)01724-0

PMID:11182455

Abstract

GABA-mediated transmission is characterized by high variability of synaptic responses. Major contributors to this variability are: presynaptic factors, including release probability and number of release sites; factors that determine synaptic GABA transients in the cleft, including diffusion and the actions of GABA transporters; and postsynaptic factors, including GABA(A) receptors subtypes, their location and number, their modulation by endogenous and exogenous factors, and their interactions with postsynaptic-anchoring proteins.

摘要

γ-氨基丁酸（GABA）介导的神经传递具有突触反应高度可变的特点。造成这种变异性的主要因素包括：突触前因素，包括释放概率和释放位点数量；决定突触间隙中GABA瞬变的因素，包括扩散和GABA转运体的作用；以及突触后因素，包括GABA(A)受体亚型、其位置和数量、其内源性和外源性因素的调节以及它们与突触后锚定蛋白的相互作用。