Programa de Pós-Graduação em Neurociências e Biologia Celular, Instituto de Ciências Biológicas, Universidade Federal do Pará, Belém 66075-110, Brazil.
Laboratório de Controle de Qualidade e Bromatologia, Curso de Farmácia, Departamento de Ciências Biológicas e da Saúde, Universidade Federal do Amapá, Macapá 68902-280, Brazil.
Molecules. 2022 Jun 4;27(11):3595. doi: 10.3390/molecules27113595.
Seizures and epilepsy are some of the most common serious neurological disorders, with approximately 80% of patients living in developing/underdeveloped countries. However, about one in three patients do not respond to currently available pharmacological treatments, indicating the need for research into new anticonvulsant drugs (ACDs). The GABAergic system is the main inhibitory system of the brain and has a central role in seizures and the screening of new ACD candidates. It has been demonstrated that the action of agents on endocannabinoid receptors modulates the balance between excitatory and inhibitory neurotransmitters; however, studies on the anticonvulsant properties of endocannabinoids from plant oils are relatively scarce. The Amazon region is an important source of plant oils that can be used for the synthesis of new fatty acid amides, which are compounds analogous to endocannabinoids. The synthesis of such compounds represents an important approach for the development of new anticonvulsant therapies.
癫痫和癫痫是最常见的严重神经疾病之一，大约 80%的患者生活在发展中/欠发达国家。然而，目前约有三分之一的患者对现有药物治疗无反应，这表明需要研究新的抗惊厥药物 (ACDs)。γ-氨基丁酸能系统是大脑的主要抑制性系统，在癫痫发作和新的 ACD 候选药物的筛选中具有核心作用。已经证明，药物对内源性大麻素受体的作用调节兴奋性和抑制性神经递质之间的平衡；然而，关于植物油脂内源性大麻素的抗惊厥特性的研究相对较少。亚马逊地区是一种可用于合成新脂肪酸酰胺的植物油脂的重要来源，而脂肪酸酰胺是与内源性大麻素类似的化合物。此类化合物的合成代表了开发新的抗惊厥疗法的重要途径。
