Marshall E
Science. 2000 Oct 20;290(5491):437-9. doi: 10.1126/science.290.5491.437.
As drug resistance renders cheap antimalarials ineffective, a promising candidate has emerged from an overlooked source: Asia. Used as herbal remedies in China for 2000 years, artemisinins haven't yet been approved for clinical use in Western countries. But abundant clinical data show that a water-soluble form called artesunate knocks down the number of parasites in the blood faster than any other drug does.
随着耐药性使廉价抗疟药物失效,一种有前景的候选药物从一个被忽视的来源出现了:亚洲。青蒿素在中国作为草药使用了2000年,但尚未在西方国家获批用于临床。不过大量临床数据表明,一种名为青蒿琥酯的水溶性形式降低血液中疟原虫数量的速度比其他任何药物都要快。