Winkler Jeffrey D, Londregan Allyn T, Ragains Justin R, Hamann Mark T
Department of Chemistry, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.
Org Lett. 2006 Jul 20;8(15):3407-9. doi: 10.1021/ol061320b.
[Structure: see text] The synthesis and biological evaluation of a series of analogues of manzamine A, representing partial structures of the pentacyclic ABCDE diamine core, is described. All new compounds were screened against Plasmodium falciparum and demonstrated attenuated antimalarial activity relative to that of manzamine A.
[结构:见正文] 描述了一系列代表五环ABCDE二胺核心部分结构的曼赞明A类似物的合成及生物学评价。所有新化合物均针对恶性疟原虫进行了筛选,结果表明其抗疟活性相对于曼赞明A有所减弱。