Couraud J Y, Koenig H, Di Giamberardino L
C R Seances Acad Sci D. 1979 Apr 23;288(15):1199-202.
Four main molecular forms of acetylcholinesterase (AChE), with sedimentation coefficients of 5, 7.5, 11.5 and 20 S, are found in Chicken ciliary ganglion. After denervation, the loss in 11.5 and 20 S forms occuring in 48 hrs coincides with the disappearance of presynaptic structures. In contrast, axotomy induces an early and durable increase in 7.5 S form. From these results, it is inferred that 11.5 and 20 S forms are predominant in presynaptic structures and 7.5 S form is mainly postsynaptic. In addition, the effects observed after simultaneous denervation and axotomy show a reciprocal control between pre- and postsynaptic elements. Finally, a trans-synaptic effect is exerted on 20 S AChE in controlateral ganglion after preganglionic sections.
在鸡睫状神经节中发现了乙酰胆碱酯酶（AChE）的四种主要分子形式，其沉降系数分别为5、7.5、11.5和20 S。去神经支配后，48小时内11.5和20 S形式的减少与突触前结构的消失同时发生。相反，轴突切断术导致7.5 S形式早期且持久增加。从这些结果可以推断，11.5和20 S形式在突触前结构中占主导，而7.5 S形式主要位于突触后。此外，同时进行去神经支配和轴突切断术后观察到的效应表明突触前和突触后元件之间存在相互控制。最后，节前切断后，对侧神经节中的20 S AChE会产生跨突触效应。
