Gangitano C, Del Fà A, Ardito G, Rumi E, Olivieri-Sangiacomo C
Boll Soc Ital Biol Sper. 1983 Jul 30;59(7):1005-9.
In the present note we have investigated the cytochemical localization of acetylcholinesterase (AChE) in the chick ciliary ganglion (CG) after post-ganglionic axotomy obtained by ablation of the eyeball. Preliminary results show at quite early stages after axotomy a remarkable reduction of cytoplasmic AChE, the residual one being localized in the rough endoplasmic reticulum. On the contrary synaptic areas, in particular those concerning the calyciform synapses, still show a marked AchE activity, similarly to what observed in physiological conditions. The decrease of cytoplasmic AChe in axotomized CG does suggest the possibility that such AChE undergoes to a topographical rearrangement moving towards the synaptic areas of ganglionic neurons.
在本报告中，我们研究了通过眼球摘除术进行节后轴突切断后，鸡睫状神经节（CG）中乙酰胆碱酯酶（AChE）的细胞化学定位。初步结果显示，在轴突切断后的相当早期阶段，细胞质AChE显著减少，残余的AChE定位于粗面内质网。相反，突触区域，特别是那些与杯状突触有关的区域，仍然显示出明显的AChE活性，这与在生理条件下观察到的情况类似。轴突切断的CG中细胞质AChE的减少确实表明，这种AChE有可能经历一种拓扑重排，向神经节神经元的突触区域移动。
