Chen R Y, Chen E Y, Chan C K, Lam L C, Lieh-Mak F
Department of Psychiatry, Queen Mary Hospital, Pokfulam, Hong Kong.
Aust N Z J Psychiatry. 2000 Feb;34(1):43-8. doi: 10.1046/j.1440-1614.2000.00647.x.
This is a study of the word production of patients with schizophrenia using a semantic verbal fluency task to address the unresolved issue of retrieval or storage impairment.
Twenty-one patients with schizophrenia and 11 matched healthy subjects performed a semantic verbal fluency task on 'food', 'animal' and 'transport' categories in Cantonese for 3 minutes each on five separate trials.
Patients generated significantly fewer numbers of words compared with control on each trial. The estimated lexicon size of the patients was significantly smaller than that of the equivalent group. The amount of shared words and variable words generated in all five trials were reduced in the patient group.
Our results suggest that poor verbal fluency in patients with schizophrenia may partly be attributable to reduction in semantic store. The importance of temporal lobe involvement on verbal fluency deficits needs to be emphasised as an integral part of the neurobiological basis of schizophrenia research.
本研究采用语义言语流畅性任务，对精神分裂症患者的词汇生成情况进行研究，以解决尚未解决的检索或存储障碍问题。
21名精神分裂症患者和11名匹配的健康受试者，就“食物”“动物”和“交通”类别，用粤语进行语义言语流畅性任务，每次3分钟，共进行5次独立试验。
在每次试验中，患者生成的单词数量显著少于对照组。患者的估计词汇量显著小于相应对照组。患者组在所有5次试验中生成的共享词和可变词数量均减少。
我们的结果表明，精神分裂症患者言语流畅性差可能部分归因于语义存储的减少。需要强调颞叶参与言语流畅性缺陷的重要性，将其作为精神分裂症研究神经生物学基础的一个组成部分。
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