Vogel Adam P, Chenery Helen J, Dart Catriona M, Doan Binh, Tan Mildred, Copland David A
Centre for Neuroscience, University of Melbourne, 7/21 Victoria Street, Melbourne, VIC, 3000, Australia.
J Psycholinguist Res. 2009 Oct;38(5):459-73. doi: 10.1007/s10936-009-9100-z. Epub 2009 Mar 4.
Lexical-semantic access and retrieval was examined in 15 adults diagnosed with schizophrenia and matched controls. This study extends the literature through the inclusion of multiple examinations of lexical-semantic production within the same patient group and through correlating performance on these tasks with various positive and negative clinical symptoms. On tasks of verbal fluency, meaning generation, sentence production using contextual information and confrontation naming, participants with schizophrenia made significantly more semantic errors on naming tasks; produced fewer meanings for homophones; produced fewer items on semantic, phonological, cued and switching fluency tasks; and produced more errors on sentence production tasks when compared to healthy controls. Significant correlations were also observed between ratings of psychomotor poverty and measures of semantic production and mental inflexibility. This study has provided additional evidence for deficits in lexical-semantic retrieval which are not due to underlying semantic store degradation, do not involve phonological based retrieval, and at the level of sentence generation appear to vary as a function of the contextual constraints provided.
对15名被诊断为精神分裂症的成年人及匹配的对照组进行了词汇语义通达与提取的研究。本研究通过在同一患者组内进行多次词汇语义生成检查，并将这些任务的表现与各种阳性和阴性临床症状相关联，从而扩展了相关文献。在言语流畅性、意义生成、利用上下文信息进行句子生成和对质命名任务中，与健康对照组相比，精神分裂症患者在命名任务中出现的语义错误显著更多；对同音词生成的意义更少；在语义、语音、线索和转换流畅性任务中生成的项目更少；在句子生成任务中出现的错误更多。还观察到精神运动迟缓评分与语义生成测量和思维灵活性之间存在显著相关性。本研究为词汇语义提取缺陷提供了更多证据，这些缺陷并非由于潜在语义存储退化所致，不涉及基于语音的提取，并且在句子生成层面似乎会根据所提供的上下文限制而有所不同。
