人型支原体临床分离株中gyrA和parC基因对氟喹诺酮耐药性决定区域的分析
[Analysis of regions determining resistence to fluoroquinolones in genes gyrA and parC in clinical isolates of Mycoplasma hominis].
作者信息
Gushchin A E, Ladygina V G, Govorun V M, Taraskina A M, Savicheva A M
机构信息
Laboratory of Gene Engineering and Immunogenetics, Institute of Physico-Chemical Medicine, Ministry of Health of Russian Federation, Moscow, St. Petersburg.
出版信息
Mol Gen Mikrobiol Virusol. 2000(4):33-5.
PMID:11186458
Abstract
Fifteen strains of M. hominis isolated from patients with urogenital inflammations were analyzed. Variations in the quinolone resistance-determining regions (QRDR) have been found in fluoroquinolone-resistant M. hominis clinical isolates in comparison with the reference PG21 strain. In one isolate, parC had Asn substitute at position 91.
摘要
对从泌尿生殖系统炎症患者中分离出的15株人型支原体进行了分析。与参考PG21菌株相比，在耐氟喹诺酮类的人型支原体临床分离株中发现了喹诺酮耐药决定区（QRDR）的变异。在一株分离株中，parC基因第91位发生了天冬酰胺替代。
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