Fan X, Ren P, Weng S, Hu G
Department of Infectious Diseases, Xiangya Hospital, Hunan Medical University, Changsha 410008.
Hunan Yi Ke Da Xue Xue Bao. 1998;23(4):391-2.
In order to elucidate the relationship between hepatitis B virus (HBV) replication and severity of hepatitis B, HBV serological markers and HBV-DNA in 56 patients with chronic hepatitis B were detected using the methods of ELISA and PCR, respectively. The results showed that the positive prevalence of HBeAg and/or HBV-DNA in chronic severe hepatitis B (5/25) was much lower than that in non-severe chronic hepatitis B (26/31) (P < 0.01). The study provides the suggestive evidence that viral replication is significantly reduced in severe hepatitis B. Also, increased replication of HBV appears to be not the cause of hepatic necrosis in severe hepatitis B.
为阐明乙型肝炎病毒（HBV）复制与乙型肝炎严重程度之间的关系，分别采用酶联免疫吸附测定（ELISA）法和聚合酶链反应（PCR）法检测了56例慢性乙型肝炎患者的HBV血清学标志物和HBV-DNA。结果显示，慢性重型乙型肝炎患者中HBeAg和/或HBV-DNA的阳性率（5/25）远低于非重型慢性乙型肝炎患者（26/31）（P<0.01）。该研究提供了提示性证据，表明重型乙型肝炎中病毒复制显著降低。此外，HBV复制增加似乎不是重型乙型肝炎肝坏死的原因。
