Shimko I A, Fokin V F
Brain Research Institute, Russian Academy of Medical Sciences, Moscow.
Zh Vyssh Nerv Deiat Im I P Pavlova. 2000 Nov-Dec;50(6):1024-34.
The pronounced benzodiazepine (antiphobic) modulation of the amplitude-temporal parameters of different components of the thalamocortical responses (TCR) of the sensorimotor cortex is observed in rabbits in their early postnatal ontogeny. This modulation is of a dose-dependent character and is registered not after the injection of tazepam in a concentration of the "therapeutic tranquilizing window" but also in the psychotoxic plasma range. A gradual increase in blood tazepam concentration in a young rabbit pup is accompanied by the wave-like and differential decrease in the amplitude of the second and third positive (P2 and P3) and third negative (N3) TCR components, while the second negative (N2) and fourth positive (P4) components tend to a wave-like increase. The dose-dependent dynamics of tazepam modulation of the P2, P3, and N3 latencies is characterized by a wave-like and differential increase. The latency of P4 decreases slightly and that of the N2 increases with a low degree of significance. The selective dynamics of benzodiazepine modulation appears to be related with peculiarities of the electrogenesis of each of the components. The dose-dependent modulation of the level of cortical DC potential is of the same character as the respective amplitude changes in P2, P3, and N3, but its fluctiatuons are more pronounced.
在出生后早期个体发育阶段的家兔中，观察到苯二氮䓬类药物（抗恐惧）对感觉运动皮层丘脑皮质反应（TCR）不同成分的幅度-时间参数有显著调节作用。这种调节具有剂量依赖性，不仅在注射处于“治疗性镇静窗口”浓度的替马西泮后可检测到，在具有精神毒性的血浆浓度范围内也可检测到。幼兔幼崽血液中替马西泮浓度的逐渐升高伴随着TCR第二和第三个正向成分（P2和P3）以及第三个负向成分（N3）幅度的波浪状和差异性降低，而第二个负向成分（N2）和第四个正向成分（P4）则呈波浪状升高趋势。替马西泮对P2、P3和N3潜伏期的剂量依赖性动态变化表现为波浪状和差异性增加。P4的潜伏期略有降低，N2的潜伏期则有低度显著性增加。苯二氮䓬类药物调节的选择性动态变化似乎与每个成分的电发生特性有关。皮质直流电位水平的剂量依赖性调节与P2、P3和N3各自的幅度变化具有相同特征，但其波动更为明显。
