Gunnarsson B, Heard C M, Martin D J, Brecher M L, Steinhorn R H
Department of Pediatrics, Children's Hospital of Buffalo and State University of New York at Buffalo, 219 Bryant Street, Buffalo, NY 14222-2099, USA.
J Perinatol. 2000 Dec;20(8 Pt 1):555-7. doi: 10.1038/sj.jp.7200466.
We describe a neonate on venoarterial extracorporeal membrane oxygenation (ECMO) with acute renal failure associated with extensive aortic and bilateral renal artery thrombosis. Concurrent anticoagulation and continuous systemic thrombolytic therapy with tissue plasminogen activator (t-PA) resulted in complete thrombolysis as evaluated by Doppler flow. The relative risk and benefits of thrombolytic therapy in heparinized patients undergoing ECMO needs to be further studied.
我们描述了一名接受静脉-动脉体外膜肺氧合（ECMO）治疗的新生儿，其患有与广泛的主动脉和双侧肾动脉血栓形成相关的急性肾衰竭。通过多普勒血流评估，同时进行抗凝和使用组织纤溶酶原激活剂（t-PA）的持续全身溶栓治疗导致血栓完全溶解。在接受ECMO治疗的肝素化患者中，溶栓治疗的相对风险和益处有待进一步研究。
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