联合溶栓和抗凝治疗早产儿双侧肾静脉血栓形成

Combination thrombolytic and anticoagulant therapy for bilateral renal vein thrombosis in a premature infant.

作者信息

Weinschenk N, Pelidis M, Fiascone J

机构信息

Division of Newborn Medicine, Department of Pediatrics, Floating Hospital for Children, Tufts University School of Medicine, Boston, Massachusetts, USA.

出版信息

Am J Perinatol. 2001 Aug;18(5):293-7. doi: 10.1055/s-2001-16993.

DOI:10.1055/s-2001-16993

PMID:11552182

Abstract

We report a premature infant with bilateral renal vein thrombosis and renal failure at 1 month of age who underwent treatment with recombinant tissue plasminogen activator and heparin sulfate. Combination thrombolytic and anticoagulation therapy was complicated by an intraventricular and intraparenchymal cerebral hemorrhage without resolution of the renal vein thrombosis. With increasing reports of successful use of this therapy for venous thrombosis, we suggest caution and continued study of its use in the premature infant and newborn.

摘要

我们报告了一名1月龄的早产婴儿，患有双侧肾静脉血栓形成和肾衰竭，接受了重组组织型纤溶酶原激活剂和硫酸肝素治疗。溶栓和抗凝联合治疗出现了脑室内和脑实质内脑出血的并发症，肾静脉血栓形成仍未缓解。随着关于这种疗法成功用于静脉血栓形成的报道不断增加，我们建议在早产婴儿和新生儿中谨慎使用并继续研究其应用。