Knadler Joseph J, Zobeck Mark, Masand Prakash, Sartain Sarah, Kyle William B
Lillie Frank Abercrombie Section of Cardiology, Department of Pediatrics, Texas Children's Hospital, Baylor College of Medicine, 6621 Fannin St, Legacy Tower, E1920, Houston, TX, 77030, USA.
Section of Hematology, Department of Pediatrics, Texas Children's Hospital, Baylor College of Medicine, 6621 Fannin St, Houston, TX, 77030, USA.
Pediatr Cardiol. 2019 Mar;40(3):658-663. doi: 10.1007/s00246-019-02068-5. Epub 2019 Feb 8.
Aortic arch thrombosis is an extremely rare but life-threatening diagnosis that is often misdiagnosed in the neonatal period. Strategies including surgical intervention, systemic anticoagulation, and thrombolysis have been previously described in the treatment of these neonates. We describe the case of a neonate who presented with concern for interrupted aortic arch and was diagnosed with an in utero aortic arch thrombosis. To our knowledge, this is the first reported case with evidence of aortic arch thrombosis in fetal life. The patient underwent successful treatment with systemic thrombolysis with tissue plasminogen activator. A brief review of the literature regarding the diagnosis, treatment, and management of neonatal aortic arch thrombosis is also presented.
主动脉弓血栓形成是一种极其罕见但危及生命的诊断，在新生儿期常被误诊。先前已有报道针对这些新生儿的治疗策略，包括手术干预、全身抗凝和溶栓治疗。我们描述了一例表现为疑似主动脉弓中断并被诊断为宫内主动脉弓血栓形成的新生儿病例。据我们所知，这是首例有胎儿期主动脉弓血栓形成证据的报道病例。该患者接受了组织型纤溶酶原激活剂全身溶栓治疗并取得成功。本文还简要回顾了有关新生儿主动脉弓血栓形成的诊断、治疗及管理的文献。
