Wagner H J, Hennig H, Jabs W J, Siekhaus A, Wessel K, Wandinger K P
Department of Pediatrics, University of Lübeck, School of Medicine, Germany.
Viral Immunol. 2000;13(4):497-502. doi: 10.1089/vim.2000.13.497.
In this study, the prevalence and reactivity of anti-Epstein-Barr virus (EBV) antibodies were investigated in 107 patients with multiple sclerosis (MS) in comparison to age- and gender-matched healthy controls from a north German state. We found a significant 100% EBV-seropositivity and a significant lack of primary EBV infections in the MS group, indicating that all MS patients are infected with EBV before the development of MS. Although there were no differences in reactivities of EBV-specific anti-early antigen (EA)-immunoglobulin G (IgG), -IgM, and -IgA antibodies between each group, MS patients had significant lower anti-Epstein-Barr nuclear antigen (EBNA)1-IgG antibody titers as a possible serological sign for a defective control of the persistent latent EBV carrier state and EBV reactivations. Longitudinal studies of MS patients are necessary to further determine the implications of EBV reactivations on the course and disease activity of MS.
在本研究中，我们调查了107例多发性硬化症（MS）患者中抗爱泼斯坦-巴尔病毒（EBV）抗体的流行情况和反应性，并与来自德国北部一个州的年龄和性别匹配的健康对照进行了比较。我们发现MS组中EBV血清阳性率显著为100%，且原发性EBV感染明显缺乏，这表明所有MS患者在MS发病前就已感染EBV。尽管每组之间EBV特异性抗早期抗原（EA）-免疫球蛋白G（IgG）、-IgM和-IgA抗体的反应性没有差异，但MS患者的抗爱泼斯坦-巴尔核抗原（EBNA）1-IgG抗体滴度显著较低，这可能是持续性潜伏EBV携带状态和EBV再激活控制缺陷的血清学标志。有必要对MS患者进行纵向研究，以进一步确定EBV再激活对MS病程和疾病活动的影响。
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