氟康唑对白色念珠菌琼脂侵袭的影响。
Effect of fluconazole on agar invasion by Candida albicans.
作者信息
Kontoyiannis Dimitrios P, Tarrand Jeffrey, Prince Randall, Samonis George, Rolston Kenneth V R
机构信息
*Section of Infectious Diseases, Department of Internal Medicine Specialties and †Department of Laboratory Medicine, University of Texas M.D. Anderson Cancer Center and ‡College of Pharmacy, University of Houston, Houston, TX, USA.
出版信息
J Med Microbiol. 2001 Jan;50(1):78-82. doi: 10.1099/0022-1317-50-1-78.
Subinhibitory concentrations of azoles are known to inhibit hyphal branching of Candida albicans in liquid media. This study showed that subinhibitory concentrations of fluconazole also inhibit agar invasion by C. albicans in YPD solid medium. Agar invasion was markedly inhibited in two C. albicans strains that were resistant to fluconazole. This suggests that the degree to which fluconazole inhibits agar invasion by C. albicans hyphae could serve as a marker of susceptibility to azoles.
已知亚抑菌浓度的唑类药物可抑制白色念珠菌在液体培养基中的菌丝分支。本研究表明，亚抑菌浓度的氟康唑也可抑制白色念珠菌在YPD固体培养基中对琼脂的侵袭。在两株对氟康唑耐药的白色念珠菌菌株中，琼脂侵袭受到显著抑制。这表明氟康唑抑制白色念珠菌菌丝对琼脂侵袭的程度可作为对唑类药物敏感性的一个指标。
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