Tümer L, Altuntaş B, Hasanoglu A, Söylemezoglu O, Arinsoy T
Department of Pediatrics, Gazi University, Gazi Hospital, Ankara, Turkey.
Pediatr Int. 2000 Dec;42(6):678-81. doi: 10.1046/j.1442-200x.2000.01311.x.
Regional variations in the human leukocyte antigen (HLA) distribution patterns of celiac disease (CD) have been reported. The aim of the present study was to assess the distribution of HLA class I and class II in Turkish children with CD and to compare the findings with a control group.
Human leukocyte antigen typing was performed in 33 children with CD and in 77 healthy individuals, who served as controls, by using standard National Institutes of Health lymphocytotoxicity techniques.
A positive association was found between HLA A2 (42 vs 19% for sick subjects compared with healthy controls, respectively), B8 (39 vs. 9% for sick subjects compared with healthy controls, respectively), CW7 (45 vs. 25% for sick subjects compared with healthy controls, respectively), DR3 (70 vs. 17% for sick subjects compared with healthy controls, respectively), DR7 (30 vs. 13% for sick subjects compared with healthy controls, respectively) and DQ2 (52 vs. 34% for sick subjects compared with healthy controls, respectively). The combinations of DR3-DQ2 (30 vs. 12% for sick subjects compared with healthy controls, respectively), DR3-DR4 (21 vs. 1% for sick subjects compared with healthy controls, respectively) and DR7-DQ2 (21 vs. 6% for sick subjects compared with healthy controls, respectively) were also found to be significantly important in children with CD. The highest relative risk (RR) was for HLA B8 in class I (RR 6.50), for DR3 (RR 11.30) in class II and for combination of DR3-DR4 (RR 20.46). The highest etiologic fraction (EF) was for the DR3 antigen (EF 0.55).
The present study emphasizes that HLA genotypes are an important background to CD development, but some additional susceptibility factors remain to be identified.
已有报道称乳糜泻（CD）患者的人类白细胞抗原（HLA）分布模式存在地区差异。本研究的目的是评估土耳其CD患儿中HLAⅠ类和Ⅱ类的分布情况，并将结果与对照组进行比较。
采用美国国立卫生研究院标准淋巴细胞毒性技术，对33例CD患儿和77例健康个体（作为对照）进行人类白细胞抗原分型。
发现HLA A2（患病个体分别为42%，健康对照为19%）、B8（患病个体分别为39%，健康对照为9%）、CW7（患病个体分别为45%，健康对照为25%）、DR3（患病个体分别为70%，健康对照为17%）、DR7（患病个体分别为30%，健康对照为13%）和DQ2（患病个体分别为52%，健康对照为34%）之间存在正相关。还发现DR3-DQ2（患病个体分别为30%，健康对照为12%）、DR3-DR4（患病个体分别为21%，健康对照为1%）和DR7-DQ2（患病个体分别为21%，健康对照为6%）的组合在CD患儿中也具有显著意义。Ⅰ类中HLA B8的相对风险（RR）最高（RR 6.50），Ⅱ类中DR3的RR最高（RR 11.30），DR3-DR4组合的RR最高（RR 20.46）。DR3抗原的病因分数（EF）最高（EF 0.55）。
本研究强调HLA基因型是CD发生的重要背景，但仍有待确定一些其他的易感因素。
