Winklhofer-Roob B M, Rossipal E, Lanzer G
Department of Paediatrics, University of Graz, Austria.
Eur J Pediatr. 1991 Aug;150(10):704-7. doi: 10.1007/BF01958759.
Regional variations in the human leucocyte antigen (HLA) distribution patterns of coeliac disease (CD) have been reported. This study focuses on phenotype frequencies of a cohort of Austrian paediatric CD patients in comparison with those recorded in the literature. HLA class I and II typing was performed in 136 CD patients and 667 healthy controls from the general population of the same geographical area. The HLA phenotypes of our controls agreed with those published for Caucasians. In our patients the relative risks (RR) were 6.43 for DR3 and 2.52 for DR7, the aetiologic fractions being 0.58 respectively 0.24. The highest RR (7.78) was found for DR3/DR7 heterozygotes. The RR for DR5 was increased in heterozygosities, either with DR3 (3.34) or DR7 (5.53), yet not for DR5 alone. Of our patients, 10% were lacking both DR3 and DR7 as well as B8, 82% of them were positive for DQw3. In these DR3 and DR7 negative patients, DR4 and DR5 were significantly more frequent than in the others. DR5 was also significantly more common in these patients compared to controls lacking the same antigens, whereas this did not hold true for DR4. Prospective studies are required to determine any link between these HLA heterogeneities and long-term progression of the disease.
乳糜泻（CD）患者人类白细胞抗原（HLA）分布模式存在地区差异已有报道。本研究聚焦于一组奥地利儿科CD患者的表型频率，并与文献中记录的频率进行比较。对来自同一地理区域普通人群的136例CD患者和667名健康对照进行了HLA I类和II类分型。我们对照组的HLA表型与已发表的高加索人表型一致。在我们的患者中，DR3的相对风险（RR）为6.43，DR7为2.52，病因分数分别为0.58和0.24。DR3/DR7杂合子的RR最高（7.78）。DR5在与DR3（3.34）或DR7（5.53）的杂合子中RR升高，但单独的DR5并非如此。我们的患者中，10%既缺乏DR3和DR7，也缺乏B8，其中82%的患者DQw3呈阳性。在这些DR3和DR7阴性的患者中，DR4和DR5的频率明显高于其他患者。与缺乏相同抗原的对照组相比，DR5在这些患者中也明显更常见，而DR4并非如此。需要进行前瞻性研究以确定这些HLA异质性与疾病长期进展之间的任何联系。
