Chan C C, Tuaillon N, Li Q, Shen D F
Section of Immunopathology, Laboratory of Immunology, National Eye Institute, National Institutes of Health, 10 Center Drive, Building 10, Room 10N103, Bethesda, MD 20892-1857, USA.
Ann N Y Acad Sci. 2000;923:141-6. doi: 10.1111/j.1749-6632.2000.tb05525.x.
Antiflammins are synthetic peptides derived from the region of highest local similarity between uteroglobulin and lipocortin. These peptides have shown anti-inflammatory activity on carrageenan-induced rat footpad edema. They are potent inhibitors for phospholipase A2 activation both in vitro and in vivo. Previously, we have demonstrated the effectiveness of topical antiflammins in suppressing acute ocular inflammation and allergic response in rodent endotoxin-induced uveitis and murine allergic conjunctivitis. The mechanisms by which antiflammins protect against inflammation and allergy in these ocular models may involve inhibition of phospholipase A2 and inducible nitric oxide synthase (iNOS) as well as the production of proinflammatory cytokine, interleukin-6.
抗炎素是从子宫球蛋白和脂皮质素之间局部相似性最高的区域衍生而来的合成肽。这些肽已显示出对角叉菜胶诱导的大鼠足垫水肿具有抗炎活性。它们在体外和体内都是磷脂酶A2激活的有效抑制剂。此前，我们已经证明局部应用抗炎素在抑制啮齿动物内毒素诱导的葡萄膜炎和小鼠过敏性结膜炎中的急性眼部炎症和过敏反应方面是有效的。在这些眼部模型中，抗炎素预防炎症和过敏的机制可能涉及抑制磷脂酶A2和诱导型一氧化氮合酶（iNOS）以及促炎细胞因子白细胞介素-6的产生。
