Chan C C, Ni M, Miele L, Cordella-Miele E, Ferrick M, Mukherjee A B, Nussenblatt R B
Laboratory of Immunology, National Eye Institute, Bethesda, Md. 20892.
Arch Ophthalmol. 1991 Feb;109(2):278-81. doi: 10.1001/archopht.1991.01080020124058.
Antiflammins are phospholipase A2-inhibitory, anti-inflammatory, synthetic oligopeptides derived from the region of the highest amino-acid sequence similarity between uteroglobin and lipocortin I. Endotoxin-induced uveitis is a model for anterior uveitis of the eye, which has been suggested to be induced through phospholipase A2 activation. In a preliminary report we demonstrated that topical administration of antiflammins could inhibit endotoxin-induced uveitis in rats. In this study, the anti-inflammatory effects of antiflammins were compared with those of corticosteroids on endotoxin-induced uveitis as measured by phospholipase A2 enzyme activity, inflammatory cell counts in the aqueous humor, and histopathologic features. Antiflammins are as effective as corticosteroids in their ability to suppress endotoxin-induced uveitis.
抗炎素是一种磷脂酶A2抑制性、抗炎性的合成寡肽，它源自子宫珠蛋白和脂皮质蛋白I之间氨基酸序列相似度最高的区域。内毒素诱导的葡萄膜炎是眼部前葡萄膜炎的一种模型，有人认为它是通过磷脂酶A2激活而诱发的。在一份初步报告中，我们证明了局部应用抗炎素可抑制大鼠内毒素诱导的葡萄膜炎。在本研究中，通过磷脂酶A2酶活性、房水中炎症细胞计数和组织病理学特征，比较了抗炎素与皮质类固醇对内毒素诱导的葡萄膜炎的抗炎作用。抗炎素在抑制内毒素诱导的葡萄膜炎方面与皮质类固醇同样有效。
