Beal M F
Department of Neurology and Neuroscience, Weill Medical College of Cornell University and New York Presbyterian Hospital, 525 East 68th Street, Room F610, New York, New York 10021, USA.
Ann N Y Acad Sci. 2000;924:164-9. doi: 10.1111/j.1749-6632.2000.tb05575.x.
There is a large body of evidence showing both metabolic defects and oxidative damage in Alzheimer's disease. Studies of cybrid cell lines show reduced cytochrome oxidase. There is also substantial evidence for a defect in alpha-ketoglutarate dehydrogenase. It is therefore possible that therapeutic strategies to improve brain metabolism or ameliorate oxidative damage might be useful in treating Alzheimer's disease.
有大量证据表明阿尔茨海默病存在代谢缺陷和氧化损伤。对细胞融合体细胞系的研究显示细胞色素氧化酶减少。也有大量证据表明α-酮戊二酸脱氢酶存在缺陷。因此，改善脑代谢或减轻氧化损伤的治疗策略可能对治疗阿尔茨海默病有用。
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