Stroke Center & Clinical Trial and Research Center for Stroke, Department of Neurology, The First Hospital of Jilin University, No. 1 Xinmin Street, Changchun 130021, China.
China National Comprehensive Stroke Center, No. 1 Xinmin Street, Changchun 130021, China.
Oxid Med Cell Longev. 2021 May 11;2021:6643382. doi: 10.1155/2021/6643382. eCollection 2021.
Oxidative stress is a key cause of ischemic stroke and an initiator of neuronal dysfunction and death, mainly through the overproduction of peroxides and the depletion of antioxidants. Ferroptosis/oxytosis is a unique, oxidative stress-induced cell death pathway characterized by lipid peroxidation and glutathione depletion. Both oxidative stress and ferroptosis/oxytosis have common molecular pathways. This review summarizes the possible targets and the mechanisms underlying the crosstalk between oxidative stress and ferroptosis/oxytosis in ischemic stroke. This knowledge might help to further understand the pathophysiology of ischemic stroke and open new perspectives for the treatment of ischemic stroke.
氧化应激是缺血性卒中的一个关键病因，也是神经元功能障碍和死亡的启动因素，主要通过过氧化物的过度产生和抗氧化剂的耗竭来实现。铁死亡/细胞凋亡是一种独特的、由氧化应激诱导的细胞死亡途径，其特征是脂质过氧化和谷胱甘肽耗竭。氧化应激和铁死亡/细胞凋亡都有共同的分子途径。本综述总结了缺血性卒中中铁死亡/细胞凋亡与氧化应激相互作用的可能靶点和机制。这些知识可能有助于进一步理解缺血性卒中的病理生理学，并为缺血性卒中的治疗开辟新的视角。
