Oruç S, Saruç M, Koyuncu F M, Ozdemir E
Department of Obstetrics and Gynecology, Celal Bayar University Medical School, Manisa, Turkey.
Aust N Z J Obstet Gynaecol. 2000 Nov;40(4):448-50. doi: 10.1111/j.1479-828x.2000.tb01179.x.
The objective of the study was to determine the changes in the plasma activities of protein C and protein S that occur during normal pregnancy In this prospective cross-sectional study, plasma activities of protein C and protein S were measured in 32 normal pregnant women in the first, second and third trimester and 6 weeks after delivery There was a significant fall in protein C and protein S activities during normal pregnancy compared with the post-puerperal period. The activities of protein C and protein S also gradually decreased throughout pregnancy (p < 0.01). Increasing plasma volume during normal pregnancy and its dilutional effect might play some role in the low activities of protein S observed. The normal falls in protein S and protein C activities make it difficult to diagnose protein S and C deficiency during pregnancy. Based on our findings, if a woman has a thromboembolic event during pregnancy, testing for a definitive diagnosis of protein C or protein S deficiency or functional failure should be delayed until at least 6 weeks postpartum.
本研究的目的是确定正常孕期血浆中蛋白C和蛋白S活性的变化。在这项前瞻性横断面研究中，对32名正常孕妇在妊娠早期、中期和晚期以及产后6周时的血浆蛋白C和蛋白S活性进行了测定。与产后相比，正常孕期蛋白C和蛋白S活性显著下降。整个孕期蛋白C和蛋白S的活性也逐渐降低（p<0.01）。正常孕期血浆量增加及其稀释作用可能在观察到的蛋白S活性降低中起一定作用。蛋白S和蛋白C活性的正常下降使得孕期诊断蛋白S和C缺乏症变得困难。根据我们的研究结果，如果一名女性在孕期发生血栓栓塞事件，对蛋白C或蛋白S缺乏症或功能衰竭进行明确诊断的检测应推迟至产后至少6周。
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