Walker M C, Garner P R, Keely E J, Rock G A, Reis M D
Department of Obstetrics and Gynecology, University of Ottawa, Ontario, Canada.
Am J Obstet Gynecol. 1997 Jul;177(1):162-9. doi: 10.1016/s0002-9378(97)70456-3.
The objective of this study was to determine the changes in activated protein C resistance that occur during normal pregnancy.
In this cross-sectional study activated protein C was measured in 128 women with normal pregnancies in the first, second, and third trimesters and in nonpregnant control subjects with 24 to 39 women in each group. In addition, factor V, factor VIII, free protein S, and functional protein C were measured and correlated with activated protein C levels. Polymerase chain reaction for factor V Leiden mutation was performed.
There was a significant fall in the activity of activated protein C in the second and third trimesters of pregnancy (p < 0.05). This was related to increased factor VIII and decreased free protein S levels (p = 0.002, R2 = 0.20). The prevalence of the factor V Leiden mutation was 7.3%.
Resistance to activated protein C is increased in the second and third trimesters of pregnancy. This is related to the alterations in other coagulation proteins, a phenomenon normally occurring during pregnancy.
本研究的目的是确定正常妊娠期间活化蛋白C抵抗的变化情况。
在这项横断面研究中，对128例妊娠各期（孕早期、孕中期和孕晚期）的正常孕妇以及非孕对照者（每组24至39名女性）进行活化蛋白C检测。此外，还检测了凝血因子V、凝血因子VIII、游离蛋白S和功能性蛋白C，并分析它们与活化蛋白C水平的相关性。进行了凝血因子V莱顿突变的聚合酶链反应检测。
妊娠中期和晚期活化蛋白C活性显著下降（p < 0.05）。这与凝血因子VIII增加和游离蛋白S水平降低有关（p = 0.002，R2 = 0.20）。凝血因子V莱顿突变的发生率为7.3%。
妊娠中期和晚期对活化蛋白C的抵抗增加。这与其他凝血蛋白的变化有关，是妊娠期间正常出现的一种现象。
