Andrews M C, Wentz A C
Am J Obstet Gynecol. 1975 Mar 15;121(6):817-28.
The effect of Danazol, a new gonadotropin inhibitor, was examined in four categories of patients. (1) Ten normal women medicated orally with Danazol, 800 mg. daily for 91 days, showed no depression of serum LH, estrone, estradiol, or progesterone below control, second-day levels. The serum FSH was slightly depressed; (2) Two anovulatory patients having elevated serum LH values were treated with Danazol, 400 to 800 mg. daily, for 1 to 3 days at midcycle. One patient repeatedly showed a temperature rise and LH flood within 24 hours of initial medication. Both had menstrual periods 7 to 9 days later. (3) Two normal midcycle ovulators were treated with 400 and 800 mg; of Danazol, respectively, for 1 day in the midfollicular phase and one apparently ovulated promptly prematurely. (4) Two patients having severe hot flushes following surgical menopause were treated with Danazol, 800 mg; daily, without reducing FSH or LH but with disappearance of hot flushes.
研究了一种新型促性腺激素抑制剂达那唑对四类患者的影响。（1）10名正常女性口服达那唑，每日800毫克，持续91天，血清促黄体生成素（LH）、雌酮、雌二醇或孕酮水平均未降至对照第2天水平以下。血清促卵泡生成素（FSH）略有下降；（2）两名血清LH值升高的无排卵患者在月经周期中期接受达那唑治疗，每日400至800毫克，持续1至3天。一名患者在初次用药后24小时内反复出现体温升高和LH峰值。两人在7至9天后均出现月经。（3）两名正常月经周期中期排卵者分别在卵泡中期接受400毫克和800毫克达那唑治疗1天，其中一人明显提前排卵。（4）两名手术绝经后出现严重潮热的患者接受达那唑治疗，每日800毫克，FSH或LH未降低，但潮热消失。
