Loiseau H, Kantor G
Clinique universitaire de neurochirurgie, hôpital Pellegrin-Tripode, place Amélie-Raba-Léon, 33076 Bordeaux, France.
Cancer Radiother. 2000 Nov;4 Suppl 1:48s-52s.
Indications for surgery in the management of glial tumors is twofold. Surgery provides a pathology-based diagnosis that is mandatory in every patient with a clinical diagnosis of glial tumor. However, its role in duration of survival is controversial. Total surgical removal is the best prognostic factor in grade 1 glioma. For grade 2 to 4 gliomas, the results of surgery are variable. Surgical resection is undoubtedly associated with clinical improvement. Its impact on duration of survival is not firmly established, due to, on the one hand, the infiltrative pattern of these types of tumors and, on the other hand, to the inherent difficulty in evaluating their size either pre- or postoperatively. However, the sole clinical improvement related to surgical resection appears sufficient to justify patients' exposure to resective surgery. The surgical risk has dramatically decreased over the last few years mainly due to technical improvements.
胶质肿瘤治疗中手术的指征有两方面。手术可提供基于病理的诊断,这对于每一位临床诊断为胶质肿瘤的患者都是必不可少的。然而,其在生存期方面的作用存在争议。全手术切除是1级胶质瘤最佳的预后因素。对于2至4级胶质瘤,手术结果各不相同。手术切除无疑与临床改善相关。其对生存期的影响尚未明确确定,一方面是由于这些类型肿瘤的浸润模式,另一方面是由于术前或术后评估其大小存在固有困难。然而,仅与手术切除相关的临床改善似乎就足以证明让患者接受切除手术是合理的。过去几年手术风险已大幅降低,这主要归功于技术进步。