局灶性皮质发育不良中的多药耐药蛋白1
Multidrug-resistance protein 1 in focal cortical dysplasia.
作者信息
Sisodiya S M, Lin W R, Squier M V, Thom M
出版信息
Lancet. 2001 Jan 6;357(9249):42-3. doi: 10.1016/s0140-6736(00)03573-x.
Abstract
Drug resistance in epilepsy is poorly understood. We used routine immunohistochemistry to assess overexpression of a multidrug-resistance protein in dysplastic neurons, glia, and around vessels in surgically resected epileptogenic human brain tissue. We showed non-tumoral overexpression of this multidrug-resistance protein, which might contribute to drug resistance in epilepsy caused by focal cortical dysplasia.
摘要
癫痫中的耐药性目前了解甚少。我们使用常规免疫组化方法评估了手术切除的致痫性人脑组织中发育异常的神经元、神经胶质细胞以及血管周围多药耐药蛋白的过表达情况。我们发现这种多药耐药蛋白在非肿瘤组织中过表达，这可能是导致局灶性皮质发育不良所致癫痫耐药的原因之一。
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