Grewal Gurpreet Kaur, Kukal Samiksha, Kanojia Neha, Saso Luciano, Kukreti Shrikant, Kukreti Ritushree
Academy of Scientific and Innovative Research (AcSIR), CSIR-Institute of Genomics and Integrative Biology (CSIR-IGIB) Campus, Delhi 110007, India.
Genomics and Molecular Medicine Unit, Institute of Genomics and Integrative Biology (IGIB), Council of Scientific and Industrial Research (CSIR), Mall Road, Delhi 110007, India.
Molecules. 2017 Feb 27;22(3):365. doi: 10.3390/molecules22030365.
Epilepsy is a neurological disorder affecting around 1%-2% of population worldwide and its treatment includes use of antiepileptic drugs to control seizures. Failure to respond to antiepileptic drug therapy is a major clinical problem and over expression of ATP-binding cassette transporters is considered one of the major reasons for pharmacoresistance. In this review, we have summarized the regulation of ABC transporters in response to oxidative stress due to disease and antiepileptic drugs. Further, ketogenic diet and antioxidants were examined for their role in pharmacoresistance. The understanding of signalling pathways and mechanism involved may help in identifying potential therapeutic targets and improving drug response.
癫痫是一种影响全球约1%-2%人口的神经系统疾病，其治疗包括使用抗癫痫药物来控制癫痫发作。对抗癫痫药物治疗无反应是一个主要的临床问题，而ATP结合盒转运蛋白的过度表达被认为是药物抵抗的主要原因之一。在这篇综述中，我们总结了ABC转运蛋白在因疾病和抗癫痫药物引起的氧化应激反应中的调节作用。此外，还研究了生酮饮食和抗氧化剂在药物抵抗中的作用。对相关信号通路和机制的理解可能有助于识别潜在的治疗靶点并改善药物反应。
