血管内皮生长因子是导致Crow-Fukase（POEMS）综合征患者发生肺动脉高压的原因。
VEGF is causative for pulmonary hypertension in a patient with Crow-Fukase (POEMS) syndrome.
作者信息
Niimi H, Arimura K, Jonosono M, Hashiguchi T, Kawabata M, Osame M, Kitajima I
机构信息
Third Department of Internal Medicine, Kagoshima University.
出版信息
Intern Med. 2000 Dec;39(12):1101-4. doi: 10.2169/internalmedicine.39.1101.
We report a case of Crow-Fukase (POEMS) syndrome associated with pulmonary hypertension (PH). In this case, the concentration of vascular endothelial growth factor (VEGF) was extremely high in the serum, and the levels of IL-1beta, IL-6, TNF-alpha, and thiamine, which were thought in past reports to be mediators of PH in Crow-Fukase syndrome, were normal. After prednisolone therapy, PH disappeared with a dramatic decrease in serum VEGF. Our results suggest that VEGF is closely correlated with PH in Crow-Fukase syndrome.
我们报告一例与肺动脉高压（PH）相关的克劳-深泽（POEMS）综合征病例。在此病例中，血清中血管内皮生长因子（VEGF）浓度极高，而过去报告中认为是克劳-深泽综合征中PH介导因子的白细胞介素-1β、白细胞介素-6、肿瘤坏死因子-α和硫胺素水平均正常。泼尼松龙治疗后，PH消失，血清VEGF显著下降。我们的结果表明，VEGF与克劳-深泽综合征中的PH密切相关。
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