Arimura H, Watanabe O, Arimura K, Maruyama I, Hokezu Y
Department of Neurology, Oita Prefectural Hospital.
Rinsho Shinkeigaku. 1997 Sep;37(9):817-23.
We report a greatly increased amount of vascular endothelial growth factor (VEGF) in sera of two cases with POEMS syndrome. They had solitary myelomas in the cervical (case 1) and lumbar vertebrae (case 2). In both cases, serum VEGF decreased after steroid therapy. Sural nerve biopsy in case 1 showed marked subperineurial edema. The pathomechanism of polyneuropathy in POEMS syndrome may be due to involvement of the blood-nerve barrier by way of increased microvascular permeability induced by VEGF. VEGF is therefore not only a useful diagnostic marker for POEMS syndrome, but may also be a marker of clinical improvement.
我们报告了两例POEMS综合征患者血清中血管内皮生长因子（VEGF）的含量大幅增加。他们分别在颈椎（病例1）和腰椎（病例2）患有孤立性骨髓瘤。在这两个病例中，血清VEGF在类固醇治疗后均下降。病例1的腓肠神经活检显示明显的神经束膜下水肿。POEMS综合征中多发性神经病的发病机制可能是由于VEGF诱导的微血管通透性增加，从而累及血-神经屏障。因此，VEGF不仅是POEMS综合征的有用诊断标志物，还可能是临床改善的标志物。
