Matsuzawa Y
Department of Internal Medicine and Molecular Science, Osaka University Graduate School of Medicine.
Nihon Rinsho. 2001 Jan;59(1):188-94.
Diabetes mellitus, hyperlipidemia, hypertension and atherosclerotic diseases have recently defined as typical life style-related diseases. A common background of these life style-related diseases is overnutrition and its consequence, obesity. Recent advances in the biology of adipose tissue have revealed that adipose is not simply an energy storage organ but it also secretes a variety of molecules which affect the metabolism of the whole body. Through a systematic search of active genes in adipose tissue, we found that adipose tissue, especially visceral fat expressed numerous genes for secretory proteins. Among them, plasminogen activator inhibitor-1(PAI-1) was over expressed in the visceral fat in an animal model of obesity. Plasma level of PAI-1 was closely correlated with visceral adiposity in human. Thus, PAI-1 secreted from visceral fat may play an important role in vascular disease in visceral obesity. Adiponectin, a novel adipose-specific gene product, is abundantly presented in human plasma. This molecule has been shown to have protective roles against atherosclerotic vascular changes and its plasma level is negatively correlated with visceral adiposity. In conclusion, dysregulated secretion of these adipose-specific secretory proteins(adipocytokines) may have important roles in the development of life style-related diseases, especially atherosclerotic diseases.
糖尿病、高脂血症、高血压和动脉粥样硬化疾病最近被定义为典型的生活方式相关疾病。这些生活方式相关疾病的一个共同背景是营养过剩及其后果——肥胖。脂肪组织生物学的最新进展表明，脂肪不仅仅是一个能量储存器官，它还分泌多种影响全身代谢的分子。通过系统搜索脂肪组织中的活性基因，我们发现脂肪组织，尤其是内脏脂肪表达了大量分泌蛋白的基因。其中，纤溶酶原激活物抑制剂-1（PAI-1）在肥胖动物模型的内脏脂肪中过度表达。人类血浆中PAI-1的水平与内脏肥胖密切相关。因此，内脏脂肪分泌的PAI-1可能在内脏肥胖的血管疾病中起重要作用。脂联素是一种新的脂肪特异性基因产物，在人体血浆中大量存在。该分子已被证明对动脉粥样硬化血管变化具有保护作用，其血浆水平与内脏肥胖呈负相关。总之，这些脂肪特异性分泌蛋白（脂肪细胞因子）的分泌失调可能在生活方式相关疾病，尤其是动脉粥样硬化疾病的发生发展中起重要作用。
