Spira I A, Rubenstein R, Wolff D, Wolff W I
Ann Surg. 1975 Jan;181(1):15-9. doi: 10.1097/00000658-197501000-00004.
A hitherto unreported clinical entity, namely fecal impaction following methadone ingestion simulating acute intestinal obstruction, is described. Five cases admitted to the Surgical Service of the Beth Israel Medical Center in New York City are discussed. The nature and pathogenesis of the obstruction are analyzed and a suggested method of managing these cases is presented. It is emphasized that with expansion and increasing acceptance of Methadone Maintenance Treatment Programs, the number of such cases will increase. It is thus important that physicians become aware of the existence of this syndrome since involvement in methadone maintenance may be a life-long commitment for persons involved, thus increasing the incidence of the complication. It is also imperative to avoid unnecessary, and possibly harmful surgical intervention in such cases.
本文描述了一种迄今为止尚未报道的临床病症，即服用美沙酮后出现粪便嵌塞，酷似急性肠梗阻。文中讨论了纽约市贝斯以色列医疗中心外科收治的5例病例。分析了梗阻的性质和发病机制，并提出了处理这些病例的建议方法。强调随着美沙酮维持治疗项目的扩大和接受度的提高，此类病例的数量将会增加。因此，医生了解这种综合征的存在非常重要，因为参与美沙酮维持治疗可能是相关人员一生的承诺，从而增加了并发症的发生率。在这种情况下，避免不必要的、可能有害的手术干预也势在必行。
