蹄叶橐吾狭苞变种叶片中的倍半萜类化合物。

Sesquiterpenes from the leaves of Ligularia fischeri var. spiciformis.

作者信息

Park H J, Kwon S H, Yoo K O, Sohn I C, Lee K T, Lee H K

出版信息

Planta Med. 2000 Dec;66(8):783-4. doi: 10.1055/s-2000-9602.

DOI:10.1055/s-2000-9602

PMID:11199147

Abstract

From the leaves of Ligularia fischeri var. spiciformis, a new eremophilanolide, 8 alpha-methoxy-6-oxoeremophil-7(11)-en-12,8-olide (6-oxoeremophilenolide) and a eudesmane-type sesquiterpene, (+)-intermedeol were isolated. The structures were determined on the basis of 2D-NMR spectral data. Data on cytotoxicity showed that the latter was clearly more potent than the former compound.

摘要

从狭苞橐吾的叶子中，分离出一种新的苦艾内酯，8α-甲氧基-6-氧代苦艾-7(11)-烯-12,8-内酯（6-氧代苦艾内酯）和一种桉叶烷型倍半萜，(+)-间型桉叶油醇。结构是基于二维核磁共振光谱数据确定的。细胞毒性数据表明，后者明显比前一种化合物更具活性。