阔苞橐吾根中的雅槛蓝烷型倍半萜衍生物。

Eremophilane-type sesquiterpene derivatives from the roots of Ligularia lapathifolia.

作者信息

Fei Dong-Qing, Li Shi-Gang, Liu Chun-Mei, Wu Gang, Gao Kun

机构信息

State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou 730000, People's Republic of China.

出版信息

J Nat Prod. 2007 Feb;70(2):241-5. doi: 10.1021/np060304k. Epub 2007 Feb 7.

DOI:10.1021/np060304k

PMID:17284071

Abstract

Six new highly oxygenated eremophilane-type sesquiterpene derivatives (1-6), including a norbisesquiterpene, were isolated from an extract of the roots of Ligularia lapathifolia, and their structures were elucidated by spectroscopic methods. The structure of 1 was confirmed by single-crystal X-ray crystallography. In addition, the cytotoxicity of compounds 1, 2, 3, 5, and 6 was evaluated against selected cancer cell lines, including human stomach carcinoma (MGC-803), human hepatoma (HEP-G2), and murine sarcoma (S-180) cell lines.

摘要

从宽叶橐吾根部提取物中分离出6种新的高氧化桉叶烷型倍半萜衍生物（1-6），包括一种降倍半萜，并用光谱方法阐明了它们的结构。通过单晶X射线晶体学确定了1的结构。此外，还评估了化合物1、2、3、5和6对选定癌细胞系的细胞毒性，包括人胃癌（MGC-803）、人肝癌（HEP-G2）和小鼠肉瘤（S-180）细胞系。