来自大花旋覆花的细胞毒性倍半萜内酯。
Cytotoxic sesquiterpene lactones from Inula britannica.
作者信息
Park E J, Kim J
出版信息
Planta Med. 1998 Dec;64(8):752-4. doi: 10.1055/s-2006-957573.
PMID:9933993
Abstract
Cytotoxicity-guided fractionation of the flowers of Inula britannica led to the isolation of four sesquiterpene lactones, 4 alpha, 6 alpha-dihydroxyeudesman-8 beta, 12-olide (1), ergolide (2), 8-epi-helenalin (3), and bigelovin (4). Compound 1 was isolated as a new natural product. These compounds showed cytotoxicity against human tumor cell lines.
摘要
对旋覆花进行细胞毒性导向的分级分离，得到了四种倍半萜内酯，即4α,6α-二羟基桉叶烷-8β,12-内酯（1）、麦角甾内酯（2）、8-表-堆心菊灵（3）和比盖洛苷（4）。化合物1作为一种新的天然产物被分离出来。这些化合物对人肿瘤细胞系显示出细胞毒性。
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